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Genetic linkage studies of this family found strong evidence for the disease gene in this family being located at chromosome 1q31.Multipoint analysis showed lod scores>3 in a 44-cm region flanked by D1S158 and D1S2781,using 80%penetrance hand a phenocopy rate of 1/50.Haplotype and multipoint analysis,including flanking markers,suggested incomplete penetrance and variable expressivity of the disease.A single affected patient who reports atypical symptoms including daily headaches likely represents a phenocopy.This new locus for hemiplegic migraine suggested that mutations of additional calcium channels in the region may cause the disease. |
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